Published studies and reviews
Reading list
The artificial-night papers take me furthest into the subject. The rabbit comparisons and the human measurements make the argument harder.
Light and altitude
The tree-shrew experiment with a simulated space rhythm and the phosphorylated-DSIP study at simulated altitude in rats anchor my interest in experimental surroundings. A rat seizure study comparing night and day adds an especially uncomfortable example of time-dependent effects.
Rabbits and human sleep
The original rabbit characterisation starts the DSIP history. I favour reading it alongside the later rabbit structure–function comparison. For the human questions, the small insomnia study and the sleep-onset plasma measurements describe importantly different kinds of observation.
Delivery and unresolved questions
The blood-incubation experiment gives the delivery discussion a physical starting point. The engineered fusion-peptide study in mice shows how far an altered molecule can take the subject. The review of DSIP's unresolved biology is a useful irritant when the individual results begin to sound like a complete explanation.
Sources
- [Effects of simulated space rhythm (L:D = 0.75h:0.75h) on circadian rhythm in tree shrews (Tupaia belangeri chinensis)] ↗
- Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude ↗
- Characterization of a delta-electroencephalogram (-sleep)-inducing peptide ↗
- [Hypnogenic properties of DSIP peptide analogs: structural-functional relationship] ↗
- The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep ↗
- Human plasma DSIP decreases at the initiation of sleep at different circadian times ↗
- Plasma concentration of nine hormones and neurotransmitters during usual activities or constant bed rest for 34 H ↗
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle ↗
- Degradation and aggregation of delta sleep-inducing peptide (DSIP) and two analogs in plasma and serum ↗
- Sleep-wave activity of a delta sleep-inducing peptide analog correlates with its penetrance of the blood-brain barrier ↗
- Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models ↗
- Neuropeptides and human sleep ↗
- Circadian effects of beta-endorphin, melatonin, DSIP, and amphetamine on pentylenetetrazol-induced seizures ↗
- Expression and Purification of Delta Sleep-Inducing Peptide Fused with Protein Transduction Domain and Human Serum Albumin in Pichia pastoris ↗
- [The hypnogenic effects of delta sleep-inducing peptide (DSIP) analogs: a comparative study in rabbits and rats] ↗